Int Arch Occup Environ Health. Genome Announc.

2012 Nov 17;23(3):529-534. doi: 10.1007/s00580-012-1645-9. DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene. Chem Biol Interact. Louei Monfared A, Jaafari A, Sheibani MT. Phenol- and p-cresol-degrading pseudomonads isolated from phenol-polluted water were analysed by the sequences of a large subunit of multicomponent phenol hydroxylase (LmPH) and catechol 2,3-dioxygenase (C23O), as well as according to the structure of the plasmid-borne pheBA operon encoding catechol 1,2-dioxygenase and single component phenol hydoxylase. Martínez-Lavanchy PM, Chen Z, Lünsmann V, Marin-Cevada V, Vilchez-Vargas R, Pieper DH, Reiche N, Kappelmeyer U, Imparato V, Junca H, Nijenhuis I, Müller JA, Kuschk P, Heipieper HJ. Environ Health Perspect.
USA.gov. Biomed Res Int. The biotransformation of phenol to both hydroquinone and catechol required NADPH and molecular oxygen. COVID-19 is an emerging, rapidly evolving situation. These results indicated that at least one step in the metabolic activation of phenol to the metabolites responsible for covalent binding to microsomal protein was mediated by cytochrome P-450. 1993 Oct;122(2):172-81. doi: 10.1006/taap.1993.1185. Epub 2014 Jan 4. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Covalent binding of radioactivity to microsomal protein was observed when [14C]phenol was incubated with rat liver microsomes in the presence of an NADPH-generating system. H��Wے۸��T�?�HY\\I"o;�zmW�8�v�Rv8Z�$N(�c����� %�E�]SCB$�ht�>}x5���ᅞ�����E�(���d�L National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The catechol and 1,2,3-trihydroxybenzene products were identified by both … P. fluorescens strains from biotypes C and F were shown to possess the pheBA operon, which was also detected in the majority of P. putida biotype B strains which use the ortho pathway for phenol degradation. The formation of catechol was inhibited by CO, the inhibitor of CYP, and correlated with the content of cytochrome P450 in microsomes. Biomed Res Int.

Vedler E, Heinaru E, Jutkina J, Viggor S, Koressaar T, Remm M, Heinaru A. Syst Appl Microbiol. Comp Clin Path. This invention relates to a process for the oxidation of phenol to a mixture of hydroquinone and catechol using hydrogen peroxide as oxidant in the presence of titanium silicate molecular sieves in a multistage fixed bed reactor. Molecular characterization of the alpha subunit of multicomponent phenol hydroxylase from 4-chlorophenol-degrading Pseudomonas sp.

It is a great challenge to balance both adhesion and water-repellent properties for coating materials because conflicting molecular characters are required.

The biotransformation was inhibited by typical cytochrome P-450 inhibitors such as carbon monoxide, SKF 525-A, and metyrapone. Clipboard, Search History, and several other advanced features are temporarily unavailable. Hepatic microsomal biotransformation of phenol to hydroquinone and catechol has been investigated with special reference to the covalent binding to microsomal protein of reactive metabolites formed during microsomal metabolism of phenol. Evidence that covalent binding of metabolically activated phenol to microsomal proteins is caused by oxidised products of hydroquinone and catechol.

2010 Aug;6(8):602-9. doi: 10.1038/nchembio.402. Phenol- and p-cresol-degrading pseudomonads isolated from phenol-polluted water were analysed by the sequences of a large subunit of multicomponent phenol hydroxylase (LmPH) and catechol 2,3-dioxygenase (C23O), as well as according to the structure of the plasmid-borne pheBA operon encoding catechol 1,2-dioxygenase and single component phenol hydoxylase.

Antonie Van Leeuwenhoek. Snyder R, Chepiga T, Yang CS, Thomas H, Platt K, Oesch F. Toxicol Appl Pharmacol. Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J. Nat Chem Biol. 2 0 obj phenol from benzene at 19 1.6 nmol/min/mg of protein, catechol from phenol at 13.6 0.3 nmol/min/mg of protein, and 1,2,3-trihydroxybenzene from catechol at 2.5 0.5nmol/min/mg of protein.

 |  These re-sults, the rst report showing the ring hydroxylation of phenol to catechol with the microsomal enzyme system of C. tropicalis, strongly suggest that CYP-catalyzed

Enrichment of bacteria possessing catechol dioxygenase genes in the rhizosphere of Spirodela polyrrhiza: a mechanism of accelerated biodegradation of phenol. Transformants containing only the pheA gene were identified due to catechol accumulation resulting in brown colonies on LB containing 1 mM phenol or by co-inoculation with the pheB-containing clone. LmPHs and C23Os clustered similarly in P. fluorescens biotype B, whereas in P. mendocina strains strong genetic heterogeneity became evident.  |  Understanding the diversity in catabolic potential of microorganisms for the development of bioremediation strategies. eCollection 2017. Hydroquinone: environmental pollution, toxicity, and microbial answers. Draft Genome Sequence of Pseudomonas nitroreducens Strain TX1, Which Degrades Nonionic Surfactants and Estrogen-Like Alkylphenols. Epub 2013 Jul 15. /Length 3686 Get the latest research from NIH: https://www.nih.gov/coronavirus. 2009 Aug;43(15):3765-76. doi: 10.1016/j.watres.2009.05.045. doi: 10.1371/journal.pone.0182484. 1993;65(1 Suppl):S147-50.  |  Toyama T, Sei K, Yu N, Kumada H, Inoue D, Hoang H, Soda S, Chang YC, Kikuchi S, Fujita M, Ike M. Water Res. Role of metabolism in benzene-induced myelotoxicity and leukemogenesis. /Filter /FlateDecode Analysis of bacterial degradation pathways for long-chain alkylphenols involving phenol hydroxylase, alkylphenol monooxygenase and catechol dioxygenase genes. eCollection 2014. Hepatic microsomal biotransformation of phenol to hydroquinone and catechol has been investigated with special reference to the covalent binding to microsomal protein of reactive metabolites formed during microsomal metabolism of phenol. Development of an immunoassay to detect hemoglobin adducts formed by benzene exposure. This site needs JavaScript to work properly. These results indicated that hydroquinone and catechol were both precursors to reactive metabolites responsible for the covalent binding. as newly detected phenol-degraders among Baltic Sea surface water bacteria characterised by comparative analysis of catabolic genes. Microbial Toluene Removal in Hypoxic Model Constructed Wetlands Occurs Predominantly via the Ring Monooxygenation Pathway. 2002 Aug;81(1-4):655-63. doi: 10.1023/a:1020534328100. NLM doi: 10.1128/genomeA.01262-13. CF600. Biodegradation. [Strategic Drug Design to Avoid the Metabolic Activation of Hepatotoxic Drugs]. %PDF-1.2 2013 Dec;36(8):525-32. doi: 10.1016/j.syapm.2013.07.004. HHS Epub 2013 Jul 15.

those of catechol. stream Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.

Catechol 2,3-dioxygenase-expressing clones were yellow on spraying with 0.5 M catechol solution.

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No significant formation of 1,2,4-benzenetriol was observed. 2013;2013:542168. doi: 10.1155/2013/542168. 2017;137(3):249-255. doi: 10.1248/yakushi.16-00230-1. %����

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