2020 Jul;94(7):2275-2292. doi: 10.1007/s00204-020-02797-0.
As can be seen from Table 72.4, the number of oxime groups does not increase reactivation ability of the potential AChE reactivator. By now, it is well-demonstrated that sugar oximes are relatively better reactivators of AChE inhibited by OPs compared with monoamine quaternary pralidoxime derivatives. Salicylaldoxime is a chelator and an extractant in hydrometallurgy. One of the two chains comprises a hydroxyl group. Chem. Organophosphorus compounds and oximes: a critical review. About half of the world's supply of cyclohexanone, more than a million tonnes annually, is converted to the oxime. The use of autoinjectors speeds the uptake of the drug because of a spraying effect as the needle plunges into the muscle, resulting in the distribution of drug within a larger muscle area, allowing for more rapid drug uptake than by using conventional needle and syringe (Sidell et al., 1974). Iran used obidoxime in small quantities in caring for Iraq War casualties in 1984 to 1987. Based on this finding, the main role in the reactivation process appears to involve just the first oxime group (with the proper pKa). a new synthesis of ethyleneimines. Findings revealed that 4-[(hydroxyimino) methyl]-1-octylpyridinium bromide (4-PAO) may be effective for the reactivation of inhibited ChE in the brain; however, its toxicity was greater than that of 2-PAM. A conceptually related reaction is the Japp–Klingemann reaction.
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