2016 Jun;124(6):703-12. doi: 10.1289/ehp.1509730. The ability of ethylene oxide to damage DNA makes it an effective sterilizing agent but also accounts for its cancer-causing activity. This article reviews key findings and scientific issues regarding the carcinogenicity of EtO in EPA's Carcinogenicity Assessment. The EPA first classified ethylene oxide (EtO) as a possible human carcinogen in 1985. 2016 Oct-Dec;770(Pt A):84-91. doi: 10.1016/j.mrrev.2016.05.002. NIH Nothing on this site should be taken as legal advice for any individual case or situation. The information on this website is for general information purposes only. Fill out the form below for a fast and FREE review of your case, and get the best options for getting the help you need now! The EPA also updated a key risk number for ethylene oxide to reflect that it was 30 times more likely to cause certain cancers than scientists had once known. In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed an evaluation of the inhalation carcinogenicity of ethylene oxide (EtO) in December 2016. Triangle Park, NC: National Institute of Environmental Health and Safety, 2016. Ethylene Oxide Exposure Attribution and Emissions Quantification Based on Ambient Air Measurements near a Sterilization Facility. In smaller amounts, ethylene oxide is used as a pesticide and a sterilizing agent. Mutat Res. How Do I Find a Good Motorcycle Accident Lawyer? People living and working within approximately two miles of this facility may have been exposed to EtO for the past three decades. It is used primarily to produce other chemicals, including antifreeze. Examination of Material Compatibilities with Ionized and Vaporized Hydrogen Peroxide Decontamination. The Environmental Protection Agency (EPA) keeps an electronic database that lists the cancer-causing potential of different substances. The weight of evidence from the epidemiologic, laboratory animal, and mechanistic studies supports a conclusion that EtO is carcinogenic in humans, with the strongest human evidence linking EtO exposure to lymphoid and breast cancers. Kirman CR, Sweeney LM, Teta MJ, Sielken RL, Valdez-Flores C, Albertini RJ, Gargas ML. The International Agency for Research on Cancer (IARC) and the United States Environmental Protection Agency (USEPA) classified ethylene oxide (EtO) as a known human carcinogen. The study concludes that the cancer risk around Sterigenics is 64 times the acceptable limit, solely because of Sterigenics’ negligent emissions. Not all humans who come into contact with carcinogens will develop cancer. NCI CPTC Antibody Characterization Program. Assessment of cancer risk from ethylene oxide residues in spices imported into New Zealand. 2020 Nov 1;59(6):703-711. doi: 10.30802/AALAS-JAALAS-19-000165. Fifteen years later, the EPA changed EtO’s status to a known human carcinogen. Critically, both noted that the epidemiological evidence based on lymphoid and breast cancers was "limited," but that the evidence in animal studies was "sufficient" and "extensive" … This information is not intended to create, and receipt or viewing does not constitute, an attorney-client relationship. Olaguer EP, Robinson A, Kilmer S, Haywood J, Lehner D. Int J Environ Res Public Health. Epub 2012 Dec 18.  |  Environ Health Perspect. Chiu WA, Jinot J, Scott CS, Makris SL, Cooper GS, Dzubow RC, Bale AS, Evans MV, Guyton KZ, Keshava N, Lipscomb JC, Barone S Jr, Fox JF, Gwinn MR, Schaum J, Caldwell JC. 2019 Oct;92(7):919-939. doi: 10.1007/s00420-019-01438-z. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Doctors and nurses constantly monitor babies to ensure their health and safety, but mothers are often less of a concern. Please enable it to take advantage of the complete set of features! Int Arch Occup Environ Health. Keywords: Assessment; breast cancer; cancer/tumors; epidemiology; ethylene oxide; genotoxicity; integrated risk information system; mode of action; mutagenesis; review. Clipboard, Search History, and several other advanced features are temporarily unavailable. Lymphoma and leukemia are the cancers most frequently reported to be associated with occupational exposure to ethylene oxide. This site needs JavaScript to work properly. Birth ... Doctors and other healthcare professionals have a responsibility and duty to ensure that they provide a standard of care established within the medical community. Epub 2016 May 20. It has been proved to cause lung cancer, mesothelioma, and many other cancers. Epub 2015 Nov 3. The U.S. Occupational Safety and Health Administration has information about limiting occupational exposure to ethylene oxide. Based on this finding, the EPA moved ethylene oxide in 2016 from a list of chemicals that probably could cause cancer to a list of chemicals that definitely caused cancer. Call or text 800-934-6555 or complete a Free Case Evaluation form. Sterigenics International in Willowbrook, Illinois is one company that has been using EtO as a sterilizing agent for medical equipment for over 30 years, and hasn’t always taken a strict-enough approach to controlling release of the gas into the environment. An air toxics study conducted by the U.S. Environmental Protection Agency (EPA) indicates that ethylene oxide emissions from the Medline Industries facility in Waukegan are responsible ... As advanced as our healthcare is, the care offered to women during childbirth is astonishingly poor. Risk Anal. This article reviews key findings and scientific issues regarding the carcinogenicity of EtO … Marsh GM, Keeton KA, Riordan AS, Best EA, Benson SM. The Environmental Protection Agency (EPA) keeps an electronic database that lists the cancer-causing potential of different substances.

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